Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. The protective and healing effects of a natural antioxidant formulation based on ubiquinol and Aloe vera against dextran sulfate-induced ulcerative colitis in rats. Korkina L, Suprun M, Petrova A, Mikhal'chik E, Luci A, De Luca C.Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Langmead L, Feakins RM, Goldthorpe S, et al.Benefit of Aloe vera and Matricaria recutita mixture in rat irritable bowel syndrome: combination of antioxidant and spasmolytic effects. Asadi-Shahmirzadi A, Mozaffari S, Sanei Y, et al.In vitro activity of Aloe vera inner gel against Helicobacter pylori strains. Cellini L, Di Bartolomeo S, Di Campli E, Genovese S, Locatelli M, Di Giulio M.Determination of in-vitro and in-vivo activities of Aloe vera L. Alginate controls heartburn in patients with erosive and nonerosive reflux disease. Savarino E, de Bortoli N, Zentilin P, et al.Inflammation and oxidative stress in gastroesophageal reflux disease. Association of acute gastroesophageal reflux disease with esophageal histologic changes. Dunbar KB, Agoston AT, Odze RD, et al. Numerous animal and human studies have demonstrated positive effects of aloe vera in other gastrointestinal conditions such as Helicobacter pylori infection, 5-6 irritable bowel syndrome, 7 ulcerative colitis, 8-9 and peptic ulcer. However, there are no clinical trials published to date on that topic. 4 Given its anti-inflammatory effects, aloe vera may be beneficial for long-term complications associated with GERD, such as Barrett's esophagus. A study published in 2012 showed that Faringel, an antacid supplement containing aloe vera gel, reduced heartburn in patients with erosive and non-erosive esophagitis. 2 Aloe vera has proven anti-inflammatory and antioxidant properties, 3 so these actions may contribute to its benefits for symptoms of GERD. 1 In 2007, Yoshida published a study also implicating inflammation and oxidative stress in GERD. A recent study published in JAMA suggests that the pathogenesis of reflux esophagitis may be due to inflammation rather than chemical injury caused by gastric acid. Other studies support the use of aloe vera in the treatment of GERD.
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